Carbonyl Reductase
Carbonyl reductase
Carbonyl reductase, an NADPH-dependent oxidoreductase, catalyzes the reduction of aldehydes and ketones to primary and secondary alcohols, respectively. This enzyme exhibits broad substrate specificity for various endogenous and xenobiotic carbonyl compounds, facilitating the reduction of endogenous prostaglandins, steroids, and other aliphatic aldehydes and ketones. Carbonyl reductases belong to the short-chain dehydrogenases/reductases (SDR) family. Among them, CBR1 plays a crucial role in protecting cells from oxidative stress-induced damage and is extensively studied for its involvement in drug metabolism, particularly in converting the chemotherapeutic agent Doxorubicin into the cardiotoxic metabolite Danurubicin. Additionally, CBR3, a target gene of the Nrf2 transcription factor, is implicated in inflammatory responses[1][2][3].
References:
- [1]. Morgan RA, et al. Carbonyl reductase 1 catalyzes 20β-reduction of glucocorticoids, modulating receptor activation and metabolic complications of obesity. Sci Rep. 2017 Sep 6;7(1):10633. [Content Brief]
- [2]. Yun M, et al. Carbonyl reductase 1 is a new target to improve the effect of radiotherapy on head and neck squamous cell carcinoma. J Exp Clin Cancer Res. 2018 Oct 30;37(1):264. [Content Brief]
- [3]. Malátková P, et al. Expression of human carbonyl reductase 3 (CBR3; SDR21C2) is inducible by pro-inflammatory stimuli. Biochem Biophys Res Commun. 2012 Apr 6;420(2):368-73. [Content Brief]
Carbonyl Reductase Isoform Specific Products
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Carbonyl Reductase Related Products (7)
Related Products (7)
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Carbonyl Reductase Isoform Comparison
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SPR inhibitor 3
0 ImagesSynonyms: SPRi3SPR inhibitor 3 (SPRi3) is a potent sepiapterin reductase (SPR) inhibitor. SPR inhibitor 3 (SPRi3) displays high binding affinity to human SPR in a cell-free assay (IC50=74 nM) and efficiently reduces biopterin levels in a cell-based assay (IC50=5.2 μM). SPR inhibitor 3 (SPRi3) reduces neuropathic and inflammatory pain through a reduction of BH4 levels.
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MonoHER
0 ImagesCat. No.: HY-121710CAS No.: 23869-24-1Synonyms: 7-MonohydroxyethylrutosideMonoHER (7-Monohydroxyethylrutoside) is a Carbonyl reductase 1 (CBR1) inhibitor and can be used as a cardioprotective agent. MonoHER inhibits the activity of CBR1 V88 and CBR1 I88 in a concentration-dependent manner.
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CBR1-IN-7
0 ImagesCat. No.: HY-157451CAS No.: 1119826-35-5CBR1-IN-7 (Compound JV-2) is a human CBR1 inhibitor (IC50=8 μM). CBR1-IN-7 can be used in cancer research.
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(8S)-Methyl zearalenone
0 ImagesCat. No.: HY-157452CAS No.: 1137720-39-8(8S)-Methyl zearalenone (ZEA analogue 5) is a selective CBR1 (carbonyl reductase 1) inhibitor, with an IC50 of 0.21 μM.
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CBR1-IN-4
0 ImagesCat. No.: HY-157447CAS No.: 1798284-64-6CBR1-IN-4 (Compound 13p) is a human carbonyl reductase 1 (CBR1) inhibitor (IC50=0.09 μM). CBR1-IN-4 can be used in cancer research.
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Cbr3 Rat Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS28634Cbr3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Cbr3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
