2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Carbonyl Reductase

Carbonyl Reductase

Carbonyl reductase

Carbonyl reductase, an NADPH-dependent oxidoreductase, catalyzes the reduction of aldehydes and ketones to primary and secondary alcohols, respectively. This enzyme exhibits broad substrate specificity for various endogenous and xenobiotic carbonyl compounds, facilitating the reduction of endogenous prostaglandins, steroids, and other aliphatic aldehydes and ketones. Carbonyl reductases belong to the short-chain dehydrogenases/reductases (SDR) family. Among them, CBR1 plays a crucial role in protecting cells from oxidative stress-induced damage and is extensively studied for its involvement in drug metabolism, particularly in converting the chemotherapeutic agent Doxorubicin into the cardiotoxic metabolite Danurubicin. Additionally, CBR3, a target gene of the Nrf2 transcription factor, is implicated in inflammatory responses[1][2][3].

Carbonyl Reductase Isoform Specific Products:

Carbonyl Reductase Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-115510
    SPR inhibitor 3
    		Inhibitor 99.01%
    SPR inhibitor 3 (SPRi3) is a potent sepiapterin reductase (SPR) inhibitor. SPR inhibitor 3 (SPRi3) displays high binding affinity to human SPR in a cell-free assay (IC50=74 nM) and efficiently reduces biopterin levels in a cell-based assay (IC50=5.2 μM). SPR inhibitor 3 (SPRi3) reduces neuropathic and inflammatory pain through a reduction of BH4 levels.
    SPR inhibitor 3
  • HY-155587
    Hydroxy-PP
    		Inhibitor 99.66%
    Hydroxy-PP is a potent carbonyl reductase 1 (CBR1) inhibitor with an IC50 value of 0.78 μM. Hydroxy-PP also potently inhibits the cytoplasmic tyrosine kinase Fyn with an IC50 value of 5 nM.
    Hydroxy-PP
  • HY-121710
    MonoHER
    		Inhibitor
    MonoHER (7-Monohydroxyethylrutoside) is a Carbonyl reductase 1 (CBR1) inhibitor and can be used as a cardioprotective agent. MonoHER inhibits the activity of CBR1 V88 and CBR1 I88 in a concentration-dependent manner.
    MonoHER
  • HY-157451
    CBR1-IN-7
    		Inhibitor
    CBR1-IN-7 (Compound JV-2) is a human CBR1 inhibitor (IC50=8 μM). CBR1-IN-7 can be used in cancer research.
    CBR1-IN-7
  • HY-157452
    (8S)-Methyl zearalenone
    		Inhibitor
    (8S)-Methyl zearalenone (ZEA analogue 5) is a selective CBR1 (carbonyl reductase 1) inhibitor, with an IC50 of 0.21 μM.
    (8S)-Methyl zearalenone
  • HY-157447
    CBR1-IN-4
    		Inhibitor
    CBR1-IN-4 (Compound 13p) is a human carbonyl reductase 1 (CBR1) inhibitor (IC50=0.09 μM). CBR1-IN-4 can be used in cancer research.
    CBR1-IN-4
  • HY-RS28634
    Cbr3 Rat Pre-designed siRNA Set A
    Cbr3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Cbr3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Cbr3 Rat Pre-designed siRNA Set A
Carbonyl Reductase Isoform Comparison

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